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Racial disparities in surgical treatment of type A acute aortic dissection

Open AccessPublished:February 09, 2023DOI:https://doi.org/10.1016/j.xjon.2023.02.002

      Abstract

      Objective

      To determine whether there are racial disparities associated with mortality, cost, and length of hospital stay after surgical repair of type A acute aortic dissection (TAAAD).

      Methods

      Patient data from 2015 to 2018 were collected using the National Inpatient Sample. In-hospital mortality was the primary outcome. Multivariable logistical modeling was used to identify factors independently associated with mortality.

      Results

      Among 3952 admissions, 2520 (63%) were White, 848 (21%) were Black/African American, 310 (8%) were Hispanic, 146 (4%) were Asian and Pacific Islander (API), and 128 (3%) were classified as Other. Black/African American and Hispanic admissions presented with TAAAD at a median age of 54 years and 55 years, respectively, whereas White and API admissions presented at a median age of 64 years and 63 years, respectively (P < .0001). Additionally, there were higher percentages of Black/African American (54%; n = 450) and Hispanic (32%; n = 94) admissions living in ZIP codes with the lowest median household income quartile. Despite these differences on presentation, when adjusting for age and comorbidity, there was no independent association between race and in-hospital mortality and no significant interactions between race and income on in-hospital mortality.

      Conclusions

      Black and Hispanic admissions present with TAAAD a decade earlier than White and API admissions. Additionally, Black and Hispanic TAAAD admissions are more likely to come from lower-income households. After adjusting for relevant cofactors, there was no independent association between race and in-hospital mortality after surgical treatment of TAAAD.

      Graphical Abstract

      Key Words

      Abbreviations and Acronyms:

      API (Asian American and Pacific Islander), AD (aortic dissection), CVD (cardiovascular disease), ICD-10 (International Classification of Diseases, 10th Revision), LOS (length of stay), MI (myocardial infarction), NIS (National Inpatient Survey), TAAAD (type A acute aortic dissection)
      Figure thumbnail fx2
      No independent association found between race and TAAAD mortality.
      Black and Hispanic patients with type A acute aortic dissection (TAAAD) present a decade earlier than White patients with TAAAD. However, there was no independent association between race and hospital mortality after TAAAD surgical treatment.
      Although mortality rate of type A acute aortic dissection (TAAAD) has been decreasing, few studies have investigated how mortality is distributed across race. Our findings suggest that Black and Hispanic patients with TAAAD are exposed to factors that predispose them to presenting a decade earlier than White patients with TAAAD. We found no independent association between race and mortality, but further investigation is needed to determine long-term outcomes.
      See Commentary on page XXX.
      Type A acute aortic dissection (TAAAD) is a rare, yet severe cardiovascular disease (CVD), with an in-hospital mortality rate of 10% to 49%.
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      The incidence and mortality of acute thoracic aortic dissection: results from a whole nation study.
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      Acute aortic dissection type A: age-related management and outcomes reported in the German Registry for Acute Aortic Dissection Type A (GERAADA) of over 2000 patients.
      Given its high mortality and morbidity, several studies have been dedicated to the diagnosis and treatment of TAAAD, and mortality rates have decreased steadily over the past several decades.
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      Improving mortality trends for hospitalization of aortic dissection in the National Inpatient Sample.
      Despite these advances, few comprehensive studies to date have investigated how these improvements in management have been distributed across race and ethnicity. This dearth of data is surprising given the significant evidence demonstrating a higher CVD burden in Black and nonwhite Hispanic patients. Several other demographic factors, such as insurance status, are significantly associated with severity of presentation and mortality from aortic procedures.
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      Insurance status is associated with acuity of presentation and outcomes for thoracic aortic operations.
      Hypertension, a primary risk factor for TAAAD, has a higher prevalence and more severe presentation in Black and nonwhite Hispanic populations.
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      Similarly, Black and nonwhite Hispanic patients have a higher prevalence of diabetes and dyslipidemia, and are at greater risk of developing associated cardiovascular complications.
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      • et al.
      Racial differences in the incidence of cardiovascular risk factors in older black and white adults.
      ,
      • Mansour O.
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      • Yeh H.-C.
      Disparities in mortality among adults with and without diabetes by sex and race.
      Additionally, the prevalence, complication rate, and mortality associated with acute CVD are higher in Black and nonwhite Hispanic patients.
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      • et al.
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      • Ogedegbe O.G.
      Interventions targeting racial/ethnic disparities in stroke prevention and treatment.
      Given the existing CVD disparities, the emergent nature of TAAAD provides a unique window into the processes of surgical care. Our hypothesis was that the greater acuity of these patients would highlight or aggravate previously observed disparities in care. Further investigation might identify patient populations with a higher incidence and mortality and potentially determine opportunities for improvement in the delivery of equitable care. Therefore, in this study, we aimed to identify whether there are racial disparities associated with mortality, cost, and hospital length of stay (LOS) after surgical repair of TAAAD (Video Abstract).

      Methods

      Identifying the Cohort

      Patient data were collected using the National Inpatient Sample (NIS) from the fourth quarter of 2015 through 2018 (n = 21,401,460). The NIS is the largest in-patient all-payer database that contains deidentified data from 20% of the nation's total discharges, representing >96% of the US population. The NIS is a restricted-access public release database and is a limited data set as defined by HIPAA [45 CFR §164.514(c)(2)]. Access is governed by a HIPAA-compliant restrictive data use agreement. This study was exempt from Institutional Review Board approval because the NIS contains deidentified patient information. Patient data in the NIS during this period were codified using the International Classification of Diseases, 10th Revision (ICD-10) codes.
      The NIS database receives racial demographic data from state-level partner organizations but does not record how each state collects demographic data. The database contains RACE as a combined racial/ethnic demographic variable with the following options: White, Black, Hispanic, Asian and Pacific Islander, Native American, and Other. If a data source provided both racial and ethnic data for an admission (ie, race, Black; ethnicity, Hispanic), the NIS ethnic data take precedence.

      Identifying the TAAAD Patient Population

      Patients were identified as having a TAAAD using the following criteria. Patients with aortic dissection were identified using the thoracic or thoracoabdominal aortic dissection ICD-10 codes (I71.01, I71.03; n = 18,431). Patients who underwent surgery for TAAAD were selected through any admission that included a surgical procedure code on the ascending aorta (n = 4943) (Table E1). It should be noted that coding of dissection does not permit distinction of ascending aortic dissection from any thoracic or thoracoabdominal dissection. Therefore, the only way to distinguish ascending aortic dissection was through the surgical codes, which make this distinction. Therefore, assessment of patients who may have presented with TAAAD but did not have surgery cannot be identified in this database. To distinguish patients with a TAAAD, nonelective admissions were selected (n = 4188) (Figure 1). We then stratified the patient population based on the RACE variable from the NIS and removed admissions with no associated RACE value (n = 236), which created a final cohort of 2520 White admissions, 848 Black/African American admissions, 310 Hispanic admissions, 146 API admissions, and 128 admissions identified as “Other.”
      Figure thumbnail gr1
      Figure 1Type A acute aortic dissection cohort selection was done using the National Inpatient Sample database for 2015 to 2018. Nonelective admissions were included if there was a thoracic or thoracoabdominal dissection diagnosis code and a surgical procedure code on the ascending aorta for a final cohort of 4204 admissions. This cohort was then stratified by the race variable. API, Asian and Pacific Islander.
      Demographic data, including age, socioeconomic status, and insurance status, and hospital data, including teaching status, region, and bed size, are provided by the NIS for each admission. Comorbidity conditions, including hypertension, prior cardiac surgery, diabetes, and peripheral vascular disease 2, were defined by a combination of ICD-10 diagnosis and procedural codes and stratified by the NIS race category (Table E2).

      Defining Outcomes

      The primary outcome for the study was in-hospital mortality of TAAAD, measured by the DIED variable. Secondary outcomes included LOS and cost of stay (TOTCHG). All charges were adjusted using the cost-to-charge ratio data provided in supplemental NIS files. Postprocedural complications were identified as a secondary outcome by combining several ICD-10 diagnosis and procedural codes (Table E3). The metric “any complication” was defined as any admission containing any ICD-10 code that described a postprocedural complication. Because the NIS does not use “present on admission” modifiers, it was difficult to determine whether certain complications, such as stroke and renal failure, were antecedent or subsequent to the surgical procedure and therefore are not reported or included in the primary outcome analysis.

      Statistical Analysis

      To identify significant differences between racial groups in both the demographic and comorbid variables, we performed the chi-square or Fisher exact test, as appropriate, for frequency analysis of discrete variables. For continuous demographic variables, which were all non-normally distributed via Kolmogorov–Smirnov/Shapiro–Wilk tests, the Kruskal–Wallis test was used to determine significance. Factors that varied significantly among different racial groups were identified using a 2-sided P value < .05. These variables were included in a multivariable regression model to determine race’s independent impact on the primary and secondary outcomes. To minimize missing data (n = 322), the “missRanger” R package was used for imputation before regression modeling. Admissions with an ICD-10 code included in Ehlers–Danlos syndrome, Turner syndrome, or congenital aortic insufficiency were excluded from multivariable regression modeling owing to insufficient sample size, per NIS HIPAA restrictions. The “other” racial category also was excluded from multivariable regression modeling. Two comorbidity index scores (readmit_score, mortal_score) were calculated using the Elixhauser Comorbidity software. Cubic spline regression was done to determine the relationship between the Elixhauser Comorbidity Index and mortality (Figure E1), and 0 was chosen as an inflection point to redefine the Elixhauser score as a dichotomous variable.

      Results

      Demographics

      Using the NIS, from the fourth quarter of 2015 to 2018, we identified a final TAAAD cohort of 3952 patient admissions. Sixty-three percent of these admissions were White (n = 2520), 21% were Black/African American (n = 848), 8% were Hispanic (n = 310), 4% were API (n = 146), and 3% identified as Other (n = 128) (Figure 2).
      Figure thumbnail gr2
      Figure 2Type A acute aortic dissection (TAAAD) cohort by race. The final cohort of TAAAD admissions included 2520 White admissions, 848 Black admissions, 310 Hispanic admissions, 146 Asian and Pacific Islander (API) admissions, and 128 admissions classified as Other.
      The majority of admissions in each racial group were from large urban teaching hospitals (Table 1). Most of Black/African American (52%) and Hispanic (42%) admissions were in hospitals located in the South, and the majority of API (71%) admissions were at hospitals in the West. Conversely, White admissions were distributed evenly throughout the various hospital regions (P < .0001) (Table 1).
      Table 1Demographic and comorbid characteristics of patients with TAAAD
      CharacteristicWhite (N = 2520)Black/African American (N = 848)Hispanic (N = 310)API (N = 146)Other (N = 128)P value
      Demographics
       Female sex, n (%)876 (35)290 (34)82 (26)58 (40)50 (39).02
       Age, yr, median (IQR)64 (54-73)54 (45-62)55 (45-65)63 (53-72)57 (49.5-68.5)<.0001
       Insurance status, n (%)<.0001
      Medicare1208 (48)222 (26)82 (26)52 (36)42 (33)
      Medicaid282 (11)208 (25)70 (23)30 (21)32 (25)
      Private insurance860 (34)308 (37)108 (35)54 (37)40 (32)
      Self-pay96 (4)66 (8)34 (11)8 (5)10 (8)
      No charge6 (0.2)12 (1)2 (1)0 (0)0 (0)
      Other58 (2)26 (3)14 (5)2 (1)2 (2)
       Median household income, percentile, n (%)<.0001
      0-25522 (21)450 (54)94 (32)14 (10)34 (27)
      26-50582 (24)154 (19)64 (22)32 (23)28 (22)
      51-75684 (28)120 (15)82 (28)22 (15)20 (16)
      75-100676 (27)102 (12)56 (19)74 (52)44 (35)
       Patient location, n (%)<.0001
      “Central” metro counties ≥1 million people562 (23)390 (47)160 (54)72 (51)72 (57)
      “Fringe” metro counties ≤1 million people680 (27)158 (19)62 (21)28 (20)38 (30)
      Metro counties with 250,000-999,999 people560 (22)162 (19)58 (19)30 (21)8 (6)
      Metro counties with 50,000-249,999 people258 (10)54 (6)6 (2)6 (4)2 (2)
      Micropolitan counties262 (11)28 (3)4 (1)2 (1)4 (3)
      Non-metro/micropolitan counties172 (7)44 (5)8 (3)4 (3)2 (2)
       Hospital region, n (%)<.0001
      Northeast546 (22)102 (12)52 (17)10 (7)48 (38)
      Midwest602 (24)214 (25)12 (4)20 (14)14 (11)
      South762 (30)438 (52)130 (42)12 (8)32 (25)
      West610 (24)94 (11)116 (37)104 (71)34 (27)
       Hospital division, n (%)<.0001
      New England166 (7)20 (2)12 (4)2 (1)4 (3)
      Middle Atlantic380 (15)82 (10)40 (13)8 (5)44 (34)
      East North Central404 (16)182 (21)6 (2)10 (7)12 (9)
      West North Central198 (8)32 (4)6 (2)10 (7)2 (2)
      South Atlantic432 (17)268 (32)72 (23)8 (5)16 (13)
      East South Central154 (6)76 (9)6 (2)2 (1)0 (0)
      West South Central176 (7)94 (11)52 (17)2 (1)16 (13)
      Mountain188 (7)22 (3)16 (5)4 (3)2 (2)
      Pacific422 (17)72 (8)100 (32)100 (68)32 (25)
       Hospital size, n (%).42
      Small142 (6)46 (5)16 (5)10 (7)8 (6)
      Medium452 (18)130 (15)56 (18)18 (12)16 (13)
      Large1926 (76)672 (79)238 (77)118 (81)104 (81)
       Hospital teaching status, n (%).0003
      Rural26 (1)4 (1)2 (1)0 (0)0 (0)
      Urban nonteaching196 (9)28 (4)22 (8)14 (11)6 (5)
      Urban teaching2012 (90)722 (96)250 (91)118 (89)108 (95)
      Comorbidities, n (%)
       Hypertension1982 (79)784 (92)274 (88)122 (84)110 (86)<.0001
       Peripheral vascular disease48 (2)24 (3)2 (1)0 (0)0 (0).02
       Chronic ischemic heart disease610 (24)150 (18)52 (17)28 (19)26 (20).0002
       Cardiac inflammation14 (1)2 (0.2)0 (0)2 (1)0 (0).19
       History of transient ischemic attack/cerebral infarction110 (4)26 (3)22 (7)4 (3)10 (8).009
       History of circulatory disease80 (3)22 (3)2 (1)0 (0)0 (0).005
       Prior cardiac surgery232 (9)50 (6)24 (8)10 (7)12 (9).04
       Presence of cardiac pacemaker52 (2)8 (1)2 (1)2 (1)0 (0).05
       Preoperative shock576 (23)166 (20)78 (25)26 (18)24 (19).09
       Aortic aneurysm274 (11)68 (8)24 (8)16 (11)28 (22)<.0001
       Chronic obstructive pulmonary disease336 (13)108 (13)16 (5)14 (10)18 (14).001
       Diabetes188 (7)106 (13)36 (12)10 (7)4 (3)<.0001
       Chronic kidney disease346 (13.7)280 (33)70 (22.6)26 (17.8)18 (14.1)<.0001
       Obesity278 (11)150 (18)50 (16)6 (4)12 (9)<.0001
       Noncompliance4 (0.2)4 (0.5)0 (0)0 (0)0 (0).35
       Marfan disease48 (1.9)12 (1.4)8 (2.5)0 (0)2 (1.6).31
      API, Asian and Pacific Islander; IQR, interquartile range; TAAAD, type A acute aortic dissection.
      Although hospital size did not differ by racial group (P = .42), there was a discrepancy in the age at admission (P < .0001). Black/African American and Hispanic admissions presented with TAAAD at a median age of 54 years and 55 years, respectively, whereas White and API admissions presented at a median age of 64 years and 63 years, respectively. On average, these data demonstrate that Black/African American and Hispanic admissions present with TAAAD approximately a decade earlier than their White and API counterparts nationwide.
      The majority of Black/African American (47%), Hispanic (54%), and API (51%) admissions were in urban, densely populated metro counties. In contrast, there was a more even distribution of White admissions between urban and metro counties (P < .0001). Furthermore, consistent with the literature,
      • Williams D.R.
      • Priest N.
      • Anderson N.B.
      Understanding associations among race, socioeconomic status, and health: patterns and prospects.
      higher percentages of Black/African American (54%) and Hispanic admissions (32%) lived in ZIP codes belonging to the lowest median household income quartile ($0 to ∼$44,000). Comparatively, the highest percentage of White admissions (28%) lived in ZIP codes from the third-highest household income quartile (∼$55,000 to $74,000), and the highest percentage of API admissions (52%) lived in ZIP codes in the highest household median quartile ($74,000+) (P < .0001). Additionally, Black/African American (25%) patients had the highest percentage of admissions covered by Medicaid. Given that White and API admissions tended to be older than other racial groups, they correspondingly had higher percentages of their admissions covered by Medicare (White, 48%; API, 36%) (P < .0001).

      Comorbidity Trends

      The most widely reported comorbidities for TAAAD include cardiovascular conditions, such as hypertension, diabetes, and prior cardiac surgery, have previously been demonstrated to be present at higher rates in underserved patient populations.
      • Mansour O.
      • Golden S.H.
      • Yeh H.-C.
      Disparities in mortality among adults with and without diabetes by sex and race.
      • Tsao C.W.
      • Aday A.W.
      • Almarzooq Z.I.
      • Alonso A.
      • Beaton A.Z.
      • Bittencourt M.S.
      • et al.
      Heart disease and stroke statistics—2022 update: a report from the American Heart Association.
      • Levine D.A.
      • Duncan P.W.
      • Nguyen-Huynh M.N.
      • Ogedegbe O.G.
      Interventions targeting racial/ethnic disparities in stroke prevention and treatment.
      Similarly, in our TAAAD admissions cohort, 92% of Black/African American admissions, 88% of Hispanic admissions, and 84% of API admissions had a diagnosis of hypertension, compared to 79% of White admissions (P < .0001) (Table 1). Additionally, there were higher rates of diabetes and obesity in Black/African American and Hispanic admissions (P = .0001) (Table 1). Chronic ischemic heart disease was found at a higher proportion in White admissions (24%) compared to Black/African American admissions (18%), Hispanic admissions (17%), and API admissions (19%) (P = .0002). Rates of preoperative shock were largely comparable across the different racial groups (P = .09).

      Primary and Secondary Outcomes

      When studying our primary outcome of in-hospital mortality, White admissions had the highest raw mortality at 17%, and Black/African American admissions had the lowest rate of raw mortality at 11% (P < .0001) (Table 2). There were no significant differences among racial groups in several different types of postoperative complications, including pulmonary complications, hemorrhage, and stroke (all P > .05). API admissions had the highest rate of postprocedural shock/cardiac failure (22%), and Black/African American admissions had the lowest rate of postprocedural shock/cardiac failure (13%). Similarly, API admissions had the highest rates of adverse reactions following a procedure (23%), whereas Black/African American and Hispanic admissions had the lowest (12% and 14%, respectively). The overall complication rate also was not significantly different across the racial groups (P = .24) (Table 2).
      Table 2Unadjusted mortality and complication rates of TAAAD
      OutcomesWhite (N = 2520)Black/African American (N = 848)Hispanic (N = 310)API (N = 146)Other (N = 128)P value
      Discharge status, n (%)
       Died438 (17)90 (11)38 (12)22 (15)14 (11)<.0001
      Resource utilization
       Length of stay, d, median (IQR)10 (6-16)11 (7-18)11 (7-17)11 (7-16)13.5 (7.5-23)<.0001
       Total cost, USD, median (IQR)290,259 (195,413-459,875)291,043 (201,132-485,816)364,646 (252,824-634,016)291,469 (205,979-584,779)368,511 (231,915-620,019)<.0001
      Complications
       Any complication1142 (45)374 (44)138 (45)70 (48)70 (55).24
       Postprocedure shock/cardiac failure400 (16)110 (13)46 (15)32 (22)32 (25).002
       Pulmonary complications616 (24)240 (28)76 (25)28 (19)36 (28).07
       Hemorrhage/hematoma/seroma182 (7)72 (8)22 (7)8 (5)12 (9).55
       Stroke52 (2)12 (1)2 (1)4 (3)4 (3).22
       Adverse reaction430 (17)102 (12)42 (14)34 (23)34 (27)<.0001
       Catheter-related complication14 (1)0 (0)0 (0)0 (0)0 (0).09
       Postprocedure hypertension14 (1)8 (1)6 (2)2 (1)0 (0).06
       Other unspecified complications24 (1)4 (0.5)2 (1)0 (0)0 (0).36
      API, Asian and Pacific Islander; IQR, interquartile range; TAAAD, type A acute aortic dissection.
      Another secondary outcome that we investigated was resource utilization. Black/African American, Hispanic, and API admissions all had a median LOS of 11 days, and White admissions had a median LOS of 10 days (P < .0001) (Table 2). Additionally, Hispanic admissions had the highest total cost at $364,646, and White admissions had the lowest total cost at $290,259 (P < .0001).

      Multivariable Regression Model

      After determining the demographic and comorbid factors that differed significantly among racial groups, we built multivariable logistic regression models using these variables to determine race’s independent association with mortality. The Elixhauser Comorbidity Index, a composite comorbidity score validated for use with administrative data, was significantly associated with mortality (odds ratio [OR], 1.029; 95% confidence interval [CI], 1.003-1.056). While the highest raw mortality was observed in White admissions, there was ultimately no association between race and hospital mortality in our multivariable model (Table 3, Figure 3). Additionally, median household income and hospital location also were not associated with mortality. We also ran analyses with several interaction variables to check for an interaction between race or median income in the setting of TAAAD mortality, but found none (Table 4). However, several comorbid variables, including increasing age (OR, 1.002; 95% CI, 1.001-1.003), chronic ischemic heart disease (OR, 1.039; 95% CI, 1.011-1.068), and preoperative shock (OR, 1.211; 95% CI, 1.011-1.068), were associated with higher mortality in TAAAD admissions. Private insurance status was more protective against TAAAD in-hospital mortality compared to the self-pay option (OR, 1.075; 95% CI, 1.021-1.131). Unexpectedly, hypertension was associated with a protective effect against mortality from TAAAD (OR, 0.934; 95% CI, 0.907-0.962). Chronic kidney disease (OR, 0.999; 95% CI, 0.970-1.028), aneurysm (OR, 1.000; 95% CI, 0.961-1.040), and Marfan syndrome (OR, 1.04; 95% CI, 0.957-1.131) showed no association with mortality.
      Table 3Independent variables associated with mortality, length of stay, and cost of stay for TAAAD
      VariableOR/estimate
      OR for in-hospital mortality; estimates for length of stay and associated cost.
      95% CIP value
      In-hospital mortality
       Age1.0021.001-1.003<.0001
       Elixhauser comorbidity index1.0291.003-1.056.027
       Race
      White (reference)
      Black/African American0.9730.944-1.003.072
      Hispanic0.9720.931-1.1013.2
      API1.0020.946-1.062.933
       Median household income percentile
      0-251
      26-501.0150.984-1.048.346
      51-751.2240.929-1.614.367
      76-1001.0470.787-1.392.720
       Insurance
      Private insurance1
      Medicare1.0240.992-1.057.137
      Medicaid1.0220.988-1.057.214
      Self-pay1.0751.021-1.131.006
      Other0.9950.930-1.065.322
       Hypertension0.9340.907-0.962<.0001
       Chronic ischemic heart disease1.0391.011-1.068.006
       Preoperative shock1.2111.179-1.243<.0001
       Chronic kidney disease0.9990.970-1.028.937
       Aneurysm1.0000.961-1.040.993
       Marfan syndrome1.040.957-1.131.351
      Length of stay
       Elixhauser comorbidity index1.2560.358-2.156.006
       Race
      White (reference)1
      Black/African American0.327−0.725 to 1.380.5
      Hispanic1.6150.142-3.088.032
      API0.452−1.566 to 2.471.66
       Insurance status
      Private insurance1
      Medicare0.672−0.425 to 1.768.229
      Medicaid1.9000.705-3.086.001
      Self-pay−1.844−3.639 to −0.049.044
      Other−3.285−9.016 to 2.446.261
       Median household income percentile
      0-251
      26-50−2.0633−3.516 to −1.311<.0001
      51-75−2.1297−3.619 to −1.433<.0001
      76-100−1.2002−3.041 to −0.803.0348
       Hypertension−1.701−2.738 to −0.664.001
       Chronic ischemic heart disease−0.290−1.243 to 0.669.556
       Preoperative shock1.6750.745-2.605<.0001
       Chronic kidney disease3.8002.781-4.812<.0001
       Aneurysm−0.955−2.322 to 0.413.171
       Marfan syndrome6.5583.651-9.465<.0001
      Associated cost, USD
       Elixhauser comorbidity index85,140.7953,726.66-116,554.92<.0001
       Race
      White (reference)1
      Black/African American−3046.50−39,814.08 to 33,721.08.871
      Hispanic156,616.55105,193.82-208,039.28<.0001
      API249,059.36177,622.48-320,496.23<.0001
       Insurance status
      Private insurance1
      Medicare11,087.86−4883.800 to 71,790.56.087
      Medicaid6171.81−17,133.25 to 66,078.58.249
      Self-pay−17,023.80−120,779.43 to 4602.75.069
      Other19,325.53−244,740.33 to 155,398.20.662
       Median household income percentile, n (%)
      0-251
      26-50−5020.85(−43,587.93, 33,546.23).799
      51-75−19,933.29(−58,132.83, 18,266.25).306
      76-10041,412.52(2211.11, 80,613.93).038
       Hypertension−63,238.99(−99,445.26, −27,032.71).0006
       Chronic ischemic heart disease−31,608.43(−65,011.43, 1794.56).064
       Preoperative shock123,883.67(91,403.90, 156,363.44)<.0001
       Chronic kidney disease128,167.62(92,702.63, 163,632.61)<.0001
       Aneurysm−46,862.50(−94,720.90, 995.91).055
       Marfan syndrome66,230.72−35,270.98 to 167,732.42.201
      Italics denote statistical significance with P value <.05.
      OR, Odds ratio; CI, confidence interval; API, Asian and Pacific Islander; TAAAD, type A acute aortic dissection.
      OR for in-hospital mortality; estimates for length of stay and associated cost.
      Figure thumbnail gr3
      Figure 3Multivariable regression model of in-hospital mortality. Forest plot representation of a multivariable regression model of in-hospital mortality, showing the Elixhauser Comorbidity Index, age, and race. Both the Elixhauser Comorbidity Index (odds ratio [OR], 1.046; 95% confidence interval [CI], 1.001-1.093) and age (OR, 1.029; 95% CI, 1.017-1.041) were independently associated with type A acute aortic dissection in-hospital mortality. However, race was not found to be independently associated with mortality. ∗P ≤ .05, ∗∗P ≤ .01, ∗∗∗P ≤ .001. API, Asian and Pacific Islander.
      Table 4Median household income interaction analysis on independent association of race and mortality
      Race × income interactionsDFOR95% CI
      Black × quartile 211.0370.962-1.116
      Black × quartile 311.0380.959-1.123
      Black × quartile 410.9860.907-1.072
      Hispanic × quartile 211.1430.954-1.281
      Hispanic × quartile 311.0470.939-1.168
      Hispanic × quartile 410.9280.824-1.046
      API × quartile 210.8590.699-1.056
      API × quartile 310.8910.718-1.106
      API × quartile 410.8320.692-1.000
      DF, Degrees of freedom; OR, odds ratio; CI, confidence interval; API, Asian and Pacific Islander.
      Although there was no association between race and mortality, we found that race was significantly associated with our secondary outcomes. Specifically, Hispanic admissions were associated with both increased LOS (day 1.615; 95% CI, 0.142-3.088) and increased cost of stay (cost $156,615.55; 95% CI, $105,193.82-$208,039.28) compared to White admissions. Interestingly, API admissions also showed an increased cost of stay (cost 249,059.36, 95% CI 177,622.48-320,496.23). Demographic characteristic such as median household income and insurance status, and comorbid variables, such as hypertension, ischemic heart disease, and preoperative shock, also were associated with both LOS and cost of stay (Table 3).

      Discussion

      TAAAD is an acute medical condition with a high mortality and severe postoperative complications. Given these risks, and the emergent nature of treatments, this syndrome provides a unique opportunity to investigate the impact of race and ethnicity on presentation and outcomes associated with emergent cardiac surgical care. Our results show that Black and Hispanic admissions present with TAAAD a decade earlier than White and API admissions. We also found that higher proportions of Black/African American and Hispanic admissions were from the lowest median household income quartile and had Medicaid insurance. Despite these differences on presentation, we found no significant association between race and surgical TAAAD in-hospital mortality. Hispanic admissions were associated with longer LOS and higher cost of stay, and API admissions had a higher associated cost of stay (Video 1).
      These data suggest that Black and Hispanic patients may be exposed to healthcare disparities that precede and predispose patients to TAAAD. Black and Hispanic patients were shown to present with TAAAD a decade earlier than White and API patients, suggesting greater exposure to TAAAD risk factors earlier in life. Two factors that may contribute to this earlier age of onset are insurance status and socioeconomic status. In our TAAAD cohort, we found higher rates of Black/African American and Hispanic patients who either were from the lowest median income quartile or were covered by Medicaid. Patients of lower socioeconomic status have been shown to have poorer access to healthy diet, are at higher risk for developing substance abuse disorders, and have higher rates of hypertension, obesity, and diabetes, all of which are risk factors for TAAAD.
      • Kabbani L.S.
      • Wasilenko S.
      • Nypaver T.J.
      • Weaver M.R.
      • Taylor A.R.
      • Abdul-Nour K.
      • et al.
      Socioeconomic disparities affect survival after aortic dissection.
      Therefore, reducing early exposure through primary prevention may be an effective strategy to address the early presentation of minority patients.
      Discrimination by healthcare providers in the primary care context also may contribute to these differences in presentation. Physicians have been shown to carry implicit bias against underserved patient populations, perceiving Black and Hispanic patients as “less cooperative, less compliant, and less responsible.”
      • Hall W.J.
      • Chapman M.V.
      • Lee K.M.
      • Merino Y.M.
      • Thomas T.W.
      • Payne B.K.
      • et al.
      Implicit racial/ethnic bias among health care professionals and its influence on health care outcomes: a systematic Review.
      Treatment biases such as these understandably have led to a growing distrust of healthcare providers and the treatments that they prescribe in underrepresented patient populations.
      • Kressin N.R.
      • Orner M.B.
      • Manze M.
      • Glickman M.E.
      • Berlowitz D.
      Understanding contributors to racial disparities in blood pressure control.
      One observed effect is a lower rate of adherence to hypertensive medication regimens in Black patient populations, which is a reported risk factor for TAAAD.
      • Kressin N.R.
      • Orner M.B.
      • Manze M.
      • Glickman M.E.
      • Berlowitz D.
      Understanding contributors to racial disparities in blood pressure control.
      Strengthening these provider–patient relationships can improve earlier screening and improve treatment adherence, which may reduce the risk for TAAAD.
      Despite disparities in presentation, it is encouraging that we found no racial disparities when looking at the association between race and TAAAD surgical mortality. This remained true even with the addition of several interaction factors, such as socioeconomic status. Interestingly, these findings run counter to other acute cardiovascular conditions. For example, Black patients have been reported to have worse surgical outcomes after abdominal aortic aneurysm repair, vascular trauma, and hemodialysis.
      • Osborne N.H.
      • Upchurch Jr., G.R.
      • Mathur A.K.
      • Dimick J.B.
      Explaining racial disparities in mortality after abdominal aortic aneurysm repair.
      • Zarkowsky D.S.
      • Arhuidese I.J.
      • Hicks C.W.
      • Canner J.K.
      • Qazi U.
      • Obeid T.
      • et al.
      Racial/ethnic disparities associated with initial hemodialysis access.
      • Hicks C.W.
      • Canner J.K.
      • Zarkowsky D.S.
      • Arhuidese I.
      • Obeid T.
      • Malas M.B.
      Racial disparities after vascular trauma are age-dependent.
      Black race has been associated with increased mortality in coronary artery bypass surgery, even after accounting for socioeconomic and clinical factors.
      • Rangrass G.
      • Ghaferi A.A.
      • Dimick J.B.
      Explaining racial disparities in outcomes after cardiac surgery: the role of hospital quality.
      Results are not uniform for all cardiac operations, however. A recent analysis in Michigan revealed that, when adjusting for clinical factors, race was not associated with mitral surgical selection or with operative outcome.
      • Pienta M.J.
      • Theurer P.F.
      • He C.
      • Zehr K.
      • Drake D.
      • Murphy E.
      • et al.
      Racial disparities in mitral valve surgery: a statewide analysis.
      Although not the case for all surgical emergencies, it may be the case that an aspect of TAAAD surgical treatment is able to equitably address the immediate mortality risk in all patient populations. Similarly, Yammine and colleagues
      • Hicks C.W.
      • Canner J.K.
      • Zarkowsky D.S.
      • Arhuidese I.
      • Obeid T.
      • Malas M.B.
      Racial disparities after vascular trauma are age-dependent.
      found that Black TAAAD patients presented earlier with greater comorbidities compared to White patients but had a lower in-hospital mortality rate. However, they also found significantly higher reintervention rates in Black patients, which also was noted in the Michigan mitral study, which similarly points to the fact that although surgical or endovascular treatment may benefit minority patient populations in the immediate context, care beyond the acute setting may need significant improvement.
      Additionally, we found that Hispanic admissions were the only ethnic group demonstrating longer LOS. Interestingly, we found no significant difference in the total postoperative complication rate when stratified by race, a variable that drives longer hospital admissions (Table 2). This finding could be due to a limitation of the NIS database, as we were unable to study many of the complications commonly associated with TAAAD, such as acute myocardial infarction, acute kidney injury, and pulmonary embolism. However, several studies also demonstrated prolonged LOS in Hispanic patient populations despite a similar rate of complications.
      • Ravi P.
      • Sood A.
      • Schmid M.
      • Abdollah F.
      • Sammon J.D.
      • Sun M.
      • et al.
      Racial/ethnic disparities in perioperative outcomes of major procedures.
      • Ghosh A.K.
      • Geisler B.P.
      • Ibrahim S.
      Racial/ethnic and socioeconomic variations in hospital length of stay: a state-based analysis.
      • Giglia M.D.
      • DeRussy A.
      • Morris M.S.
      • Richman J.S.
      • Hawn M.T.
      • Vickers S.M.
      • et al.
      Racial disparities in length-of-stay persist even with no postoperative complications.
      • Elsamadicy A.A.
      • Koo A.B.
      • David W.B.
      • Sarkozy M.
      • Freedman I.G.
      • Reeves B.C.
      • et al.
      Portending influence of racial disparities on extended length of stay after elective anterior cervical discectomy and interbody fusion for cervical spondylotic myelopathy.
      It has been speculated that these race-specific differences could be due to disparities in housing security, which could affect safe hospital discharge. Another possibility is that this prolonged LOS is a reflection of provider bias, which has been shown to foster patient distrust, poor patient–provider communication, and greater patient stress, all of which could impact a patient’s postoperative course.
      We also found that Hispanics and API admissions had higher costs of stay. This finding is less likely to be fully attributable to LOS, given that Hispanic admissions were longer by only 1 day, and API admissions were not found to be significantly longer. The higher cost of API admissions may be related to the finding that a higher proportion of API admissions belonged to the highest income quartile. These patients may access specialty care that may lead to higher costs without a corresponding increase in LOS. However, owing to the heterogeneity of these patient populations, and the lack of data surrounding previous access to healthcare and common complications, further study with a clinically driven descriptive database may be necessary to understand this difference in outcome.
      Other studies using self-reporting methods have also pointed to likely racial disparities in aortic dissection. In a small retrospective study looking at a single institution, Black patients with aortic dissection were significantly younger, had poorer hypertension control, and required a greater number of reinterventions than their white counterparts.
      • Lackland D.T.
      Racial differences in hypertension: implications for high blood pressure management.
      Owing to the rarity of acute aortic dissection, the study included a cohort of only 126 patients with type B aortic dissections. Another retrospective study investigating all acute hospitals in Maryland observed higher rates of hospitalization for all aortic dissections in non-White patients.
      • Howard G.
      • Safford M.M.
      • Moy C.S.
      • Howard V.J.
      • Kleindorfer D.O.
      • Unverzagt F.W.
      • et al.
      Racial differences in the incidence of cardiovascular risk factors in older black and white adults.
      Additionally, one nationwide study investigating the different types of aortic dissection in the early 2000s listed race as a significant determinant of mortality but failed to investigate this finding further.
      • Zimmerman K.P.
      • Oderich G.
      • Pochettino A.
      • Hanson K.T.
      • Habermann E.B.
      • Bower T.C.
      • et al.
      Improving mortality trends for hospitalization of aortic dissection in the National Inpatient Sample.
      Although limited in scope, each of these studies pointed toward existing racial disparities in the development and presentation of aortic dissection, but further investigation is needed to gain a more comprehensive understanding of how this condition impacts underrepresented patient populations across the entire spectrum of disease.
      Our study was subject to several limitations. First, the NIS does not distinguish whether a condition was present on admission or was a postoperative complication. Therefore, even though we did not observe differences in mortality, further investigation is needed to identify any significant differences in complications among racial groups. The NIS contains only deidentified admission data, which prevented longitudinal analysis of any individual patient’s care. For instance, we were unable to determine access to medical care prior to the patient’s TAAAD admission, nor were we able to study any follow-up care or longitudinal mortality. For instance, we were unable to determine differences in aneurysm burden between racial groups on admission, as the NIS does not provide clear indicators between diagnoses present on admission versus a postoperative complication. Additionally, because the NIS is an administrative database, it provides no diagnostic clinical details of a patient’s status that would have been included in a clinical registry. For example, we were not able to distinguish between patients who had well-controlled hypertension and those with poorly controlled hypertension, which would have a significant impact on the development of TAAAD. Finally, because we focused on patients who had undergone surgery, the data did not permit us to identify patients presenting with TAAAD who did not undergo surgery and thus may have masked potential selection bias.

      Conclusions

      Black/African American and Hispanic TAAAD admissions have higher rates of Medicaid coverage and hypertension, and lower socioeconomic status compared to their White and API counterparts. Additionally, Black and Hispanic patients present with TAAAD 10 years younger than their White and API counterparts. Despite these disparities, after adjusting for potential confounding variables, there was no association between race and TAAAD surgical mortality, but Hispanic TAAAD admissions were found to have longer LOS and higher costs of stay, and API admissions had higher costs of stay, compared to White admissions. Further investigation is needed to identify any racial disparities in associated postoperative complications in addition to other phases of care (Figure 4).

      Conflict of Interest Statement

      The authors reported no conflicts of interest.
      The Journal policy requires editors and reviewers to disclose conflicts of interest and to decline handling or reviewing manuscripts for which they may have a conflict of interest. The editors and reviewers of this article have no conflicts of interest.

      Supplementary Data

      Appendix 1

      Table E1ICD-10 surgical procedure codes for the ascending aorta
      ICD-10 codeDescription
      02QX0ZZRepair thoracic aorta, ascending/arch, open approach
      02UX07ZSupplement thoracic aorta, ascending/arch with autologous tissue substitute, open approach
      02UX08ZSupplement thoracic aorta, ascending/arch with zooplastic tissue, open approach
      02UX0JZSupplement thoracic aorta, ascending/arch with synthetic substitute, open Approach
      02UX0KZSupplement thoracic aorta, ascending/arch with nonautologous tissue substitute, open approach
      02VX0CZRestriction of thoracic aorta, ascending/arch with extraluminal device, open approach
      02VX0DZRestriction of thoracic aorta, ascending/arch with intraluminal device, open approach
      02VX0EZRestriction of thoracic aorta, ascending/arch with branched or fenestrated intraluminal device, one or two arteries, open approach
      02VX0FZRestriction of thoracic aorta, ascending/arch with branched or fenestrated intraluminal device, three or more arteries, open approach
      02VX0ZZRestriction of thoracic aorta, ascending/arch, open approach
      02BX0ZZExcision of thoracic aorta, ascending/arch, open approach
      02RX07ZReplacement of thoracic aorta, ascending/arch with autologous tissue substitute, open approach
      02RX08ZReplacement of thoracic aorta, ascending/arch with zooplastic tissue, open approach
      02RX0JZReplacement of thoracic aorta, ascending/arch with synthetic substitute, open approach
      02RX0KZReplacement of thoracic aorta, ascending/arch with nonautologous tissue substitute, open approach
      ICD-10, International Classification of Diseases, Tenth Revision.
      Table E2ICD-10 codes for comorbidities
      ICD-10 codeDescription
      Hypertension
       I10Essential (primary) hypertension
       I11Hypertensive heart disease
       I12Hypertensive kidney disease
       I13Hypertensive heart and chronic kidney disease
       I15Secondary hypertension
       I16Hypertensive crisis
       I110Hypertensive heart disease with heart failure
       I119Hypertensive heart disease without heart failure
       I120Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease
       I129Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
       I130Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease or unspecified chronic kidney disease
       I1310Hypertensive heart and chronic kidney disease without heart failure with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
       I1311Hypertensive heart and chronic kidney disease without heart failure with stage 5 chronic kidney disease, or end stage renal disease
       I132Hypertensive heart and chronic kidney disease with heart failure with stage 5 chronic kidney disease, or end stage renal disease
       I150Renovascular hypertension
       I151Hypertension secondary to other renal disorders
       I152Hypertension secondary to endocrine disorders
       I158Other secondary hypertension
       I159Secondary hypertension, unspecified
       I160Hypertensive urgency
       I161Hypertensive emergency
       I169Hypertensive crisis, unspecified
      Peripheral vascular disease
       I70Atherosclerosis
       I701Atherosclerosis of renal artery
       I702Atherosclerosis of native arteries of the extremities
       I7020Unspecified atherosclerosis of native arteries of extremities
       I70201Unspecified atherosclerosis of native arteries of extremities right leg
       I70202Unspecified atherosclerosis of native arteries of extremities left leg
       I70203Unspecified atherosclerosis of native arteries of extremities bilateral legs
       I70208Unspecified atherosclerosis of native arteries of extremities other extremity
       I70209Unspecified atherosclerosis of native arteries of extremities unspecified extremity
       I7021Atherosclerosis of native arteries of extremities with intermittent claudication
       I70211Atherosclerosis of native arteries with intermittent claudication right leg
       I70212Atherosclerosis of native arteries with intermittent claudication left leg
       I70213Atherosclerosis of native arteries with intermittent claudication bilateral legs
       I70218Atherosclerosis of native arteries with intermittent claudication other extremity
       I70219Atherosclerosis of native arteries with intermittent claudication unspecified extremity
       I7022Atherosclerosis of native arteries of extremities with rest pain
       I70221Atherosclerosis of native arteries of extremities with rest pain right leg
       I70222Atherosclerosis of native arteries of extremities with rest pain left leg
       I70223Atherosclerosis of native arteries of extremities with rest pain bilateral legs
       I70228Atherosclerosis of native arteries of extremities with rest pain other extremity
       I70229Atherosclerosis of native arteries of extremities with rest pain unspecified extremity
       I7023Atherosclerosis of native arteries of right leg with ulceration
       I70231Atherosclerosis of native arteries of right leg with ulceration of thigh
       I70232Atherosclerosis of native arteries of right leg with ulceration of calf
       I70233Atherosclerosis of native arteries of right leg with ulceration of ankle
       I70234Atherosclerosis of native arteries of right leg with ulceration of heel and midfoot
       I70235Atherosclerosis of native arteries of right leg with ulceration of other part of foot
       I70238Atherosclerosis of native arteries of right leg with ulceration of other part of lower leg
       I70239Atherosclerosis of native arteries of right leg with ulceration of unspecified site
       I7024Atherosclerosis of native arteries of left leg with ulceration
       I70241Atherosclerosis of native arteries of left leg with ulceration of thigh
       I70242Atherosclerosis of native arteries of left leg with ulceration of calf
       I70243Atherosclerosis of native arteries of left leg with ulceration of ankle
       I70244Atherosclerosis of native arteries of left leg with ulceration of heel and midfoot
       I70245Atherosclerosis of native arteries of left leg with ulceration of other part of foot
       I70248Atherosclerosis of native arteries of left leg with ulceration of other part of lower leg
       I70249Atherosclerosis of native arteries of left leg with ulceration of unspecified site
       I7025Atherosclerosis of native arteries of other extremities with ulceration
       I7026Atherosclerosis of native arteries of extremities with gangrene
       I70261Atherosclerosis of native arteries of extremities with gangrene right leg
       I70262Atherosclerosis of native arteries of extremities with gangrene left leg
       I70263Atherosclerosis of native arteries of extremities with gangrene bilateral legs
       I70268Atherosclerosis of native arteries of extremities with gangrene other extremity
       I70269Atherosclerosis of native arteries of extremities with gangrene unspecified extremity
       I7029Other atherosclerosis of native arteries of extremities
       I70291Other atherosclerosis of native arteries of extremities right leg
       I70292Other atherosclerosis of native arteries of extremities left leg
       I70293Other atherosclerosis of native arteries of extremities bilateral legs
       I70298Other atherosclerosis of native arteries of extremities other extremity
       I70299Other atherosclerosis of native arteries of extremities unspecified extremity
       I703Atherosclerosis of unspecified type of bypass graft(s) of the extremities
       I7030Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities
       I70301Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities right leg
       I70302Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities left leg
       I70303Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities bilateral legs
       I70308Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities other extremity
       I70309Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities unspecified extremity
       I7031Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication
       I70311Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication right leg
       I70312Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication left leg
       I70313Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication bilateral legs
       I70318Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication other extremity
       I70319Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication unspecified extremity
       I7032Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain
       I70321Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain right leg
       I70322Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain left leg
       I70323Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain bilateral legs
       I70328Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain other extremity
       I70329Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain unspecified extremity
       I7033Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration
       I70331Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of thigh
       I70332Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of calf
       I70333Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of ankle
       I70334Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of heel and midfoot
       I70335Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of other part of foot
       I70338Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of other part of lower leg
       I70339Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of unspecified site
       I7034Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration
       I70341Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of thigh
       I70342Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of calf
       I70343Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of ankle
       I70344Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of heel and midfoot
       I70345Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of other part of foot
       I70348Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of other part of lower leg
       I70349Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of unspecified site
       I7035Atherosclerosis of unspecified type of bypass graft(s) of other extremity with ulceration
       I7036Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene
       I70361Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene right leg
       I70362Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene left leg
       I70363Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene bilateral legs
       I70368Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene other extremity
       I70369Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene unspecified extremity
       I7039Other atherosclerosis of unspecified type of bypass graft(s) of the extremities
       I70391Other atherosclerosis of unspecified type of bypass graft(s) of the extremities right leg
       I70392Other atherosclerosis of unspecified type of bypass graft(s) of the extremities left leg
       I70393Other atherosclerosis of unspecified type of bypass graft(s) of the extremities bilateral legs
       I70398Other atherosclerosis of unspecified type of bypass graft(s) of the extremities other extremity
       I70399Other atherosclerosis of unspecified type of bypass graft(s) of the extremities unspecified extremity
       I704Atherosclerosis of autologous vein bypass graft(s) of the extremities
       I7040Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities
       I70401Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities right leg
       I70402Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities left leg
       I70403Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities bilateral legs
       I70408Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities other extremity
       I70409Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities unspecified extremity
       I7041Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication
       I70411Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication right leg
       I70412Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication left leg
       I70413Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication bilateral legs
       I70418Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication other extremity
       I70419Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication unspecified extremity
       I7042Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain
       I70421Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain right leg
       I70422Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain left leg
       I70423Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain bilateral legs
       I70428Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain other extremity
       I70429Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain unspecified extremity
       I7043Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration
       I70431Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of thigh
       I70432Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of calf
       I70433Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of ankle
       I70434Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of heel and midfoot
       I70435Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of other part of foot
       I70438Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of other part of lower leg
       I70439Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of unspecified site
       I7044Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration
       I70441Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of thigh
       I70442Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of calf
       I70443Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of ankle
       I70444Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of heel and midfoot
       I70445Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of other part of foot
       I70448Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of other part of lower leg
       I70449Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of unspecified site
       I7045Atherosclerosis of autologous vein bypass graft(s) of other extremity with ulceration
       I7046Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene
       I70461Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene right leg
       I70462Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene left leg
       I70463Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene bilateral legs
       I70468Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene other extremity
       I70469Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene unspecified extremity
       I7049Other atherosclerosis of autologous vein bypass graft(s) of the extremities
       I70491Other atherosclerosis of autologous vein bypass graft(s) of the extremities, right leg
       I70492Other atherosclerosis of autologous vein bypass graft(s) of the extremities, left leg
       I70493Other atherosclerosis of autologous vein bypass graft(s) of the extremities, bilateral legs
       I70498Other atherosclerosis of autologous vein bypass graft(s) of the extremities, other extremity
       I70499Other atherosclerosis of autologous vein bypass graft(s) of the extremities, unspecified extremity
       I705AAtherosclerosis of nonautologous biological bypass graft(s) of the extremities
       I7050Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities
       I70501Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities, right leg
       I70502Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities, left leg
       I70503Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities, bilateral legs
       I70508Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities, other extremity
       I70509Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities, unspecified extremity
       I7051Atherosclerosis of nonautologous biological bypass graft(s) of the extremities, intermittent claudication
       I70511Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, right leg
       I70512Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, left leg
       I70513Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, bilateral legs
       I70518Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, other extremity
       I70519Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, unspecified extremity
       I7052Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain
       I70521Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain, right leg
       I70522Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain, left leg
       I70523Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain, bilateral legs
       I70528Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain, other extremity
       I70529Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain, unspecified extremity
       I7053Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration
       I70531Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of thigh
       I70532Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of calf
       I70533Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of ankle
       I70534Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of heel and midfoot
       I70535Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of other part of foot
       I70538Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of other part of lower leg
       I70539Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of unspecified site
       I7054Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration
       I70541Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of thigh
       I70542Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of calf
       I70543Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of ankle
       I70544Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of heel and midfoot
       I70545Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of other part of foot
       I70548Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of other part of lower leg
       I70549Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of unspecified site
       I7055Atherosclerosis of nonautologous biological bypass graft(s) of other extremity with ulceration
       I7056Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene
       I70561Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene, right leg
       I70562Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene, left leg
       I70563Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene, bilateral legs
       I70568Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene, other extremity
       I70569Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene, unspecified extremity
       I7059Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities
       I70591Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities, right leg
       I70592Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities, left leg
       I70593Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities, bilateral legs
       I70598Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities, other extremity
       I70599Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities, unspecified extremity
       I706Atherosclerosis of nonbiological bypass graft(s) of the extremities
       I7060Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities
       I70601Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities, right leg
       I70602Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities, left leg
       I70603Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities, bilateral legs
       I70608Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities, other extremity
       I70609Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities, unspecified extremity
       I7061Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication
       I70611Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, right leg
       I70612Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, left leg
       I70613Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, bilateral legs
       I70618Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, other extremity
       I70619Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, unspecified extremity
       I7062Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain
       I70621Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain, right leg
       I70622Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain, left leg
       I70623Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain, bilateral legs
       I70628Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain, other extremity
       I70629Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain, unspecified extremity
       I7063Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration
       I70631Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of thigh
       I70632Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of calf
       I70633Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of ankle
       I70634Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of heel and midfoot
       I70635Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of other part of foot
       I70638Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of other part of lower leg
       I70639Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of unspecified site
       I7064Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration
       I70641Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of thigh
       I70642Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of calf
       I70643Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of ankle
       I70644Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of heel and midfoot
       I70645Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of other part of foot
       I70648Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of other part of lower leg
       I70649Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of unspecified site
       I7065Atherosclerosis of nonbiological bypass graft(s) of other extremity with ulceration
       I7066Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene
       I70661Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene, right leg
       I70662Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene, left leg
       I70663Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene, bilateral legs
       I70668Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene, other extremity
       I70669Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene, unspecified extremity
       I7069Other atherosclerosis of nonbiological bypass graft(s) of the extremities
       I70691Other atherosclerosis of nonbiological bypass graft(s) of the extremities, right leg
       I70692Other atherosclerosis of nonbiological bypass graft(s) of the extremities, left leg
       I70693Other atherosclerosis of nonbiological bypass graft(s) of the extremities, bilateral legs
       I70698Other atherosclerosis of nonbiological bypass graft(s) of the extremities, other extremity
       I70699Other atherosclerosis of nonbiological bypass graft(s) of the extremities, unspecified extremity
       I707Atherosclerosis of other type of bypass graft(s) of the extremities
       I7070Unspecified atherosclerosis of other type of bypass graft(s) of the extremities
       I70701Unspecified atherosclerosis of other type of bypass graft(s) of the extremities, right leg
       I70702Unspecified atherosclerosis of other type of bypass graft(s) of the extremities, left leg
       I70703Unspecified atherosclerosis of other type of bypass graft(s) of the extremities, bilateral legs
       I70708Unspecified atherosclerosis of other type of bypass graft(s) of the extremities, other extremity
       I70709Unspecified atherosclerosis of other type of bypass graft(s) of the extremities, unspecified extremity
       I7071Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication
       I70711Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, right leg
       I70712Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, left leg
       I70713Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, bilateral legs
       I70718Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, other extremity
       I70719Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, unspecified extremity
       I7072Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain
       I70721Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain, right leg
       I70722Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain, left leg
       I70723Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain, bilateral legs
       I70728Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain, other extremity
       I70729Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain, unspecified extremity
       I7073Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration
       I70731Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of thigh
       I70732Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of calf
       I70733Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of ankle
       I70734Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of heel and midfoot
       I70735Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of other part of foot
       I70738Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of other part of lower leg
       I70739Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of unspecified site
       I7074Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration
       I70741Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of thigh
       I70742Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of calf
       I70743Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of ankle
       I70744Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of heel and midfoot
       I70745Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of other part of foot
       I70748Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of other part of lower leg
       I70749Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of unspecified site
       I7075Atherosclerosis of other type of bypass graft(s) of other extremity with ulceration
       I7076Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene
       I70761Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene, right leg
       I70762Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene, left leg
       I70763Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene, bilateral legs
       I70768Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene, other extremity
       I70769Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene, unspecified extremity
       I7079Other atherosclerosis of other type of bypass graft(s) of the extremities
       I70791Other atherosclerosis of other type of bypass graft(s) of the extremities, right leg
       I70792Other atherosclerosis of other type of bypass graft(s) of the extremities, left leg
       I70793Other atherosclerosis of other type of bypass graft(s) of the extremities, bilateral legs
       I70798Other atherosclerosis of other type of bypass graft(s) of the extremities, other extremity
       I70799Other atherosclerosis of other type of bypass graft(s) of the extremities, unspecified extremity
       I708Atherosclerosis of other arteries
       I709Other and unspecified atherosclerosis
       I7090Unspecified atherosclerosis
       I7091Generalized atherosclerosis
       I7092Chronic total occlusion of artery of the extremities
       Z8679Personal history of other diseases of the circulatory system
      COPD
       J43Emphysema
       J430Unilateral pulmonary emphysema
       J431Panlobular emphysema
       J432Centrilobular emphysema
       J438Other emphysema
       J439Emphysema, unspecified
       J449Chronic obstructive pulmonary disease, unspecified
       J44Other chronic obstructive pulmonary disease
       J440Chronic obstructive pulmonary disease with (acute) lower respiratory infection
       J441Chronic obstructive pulmonary disease with (acute) exacerbation
       J442Chronic obstructive pulmonary disease, unspecified
      Marfan syndrome
       Q8740Marfan syndrome unspecified
       Q8741Marfan syndrome with cardiovascular manifestations
       Q87410Marfan syndrome with aortic dilation
       Q87418Marfan syndrome with other cardiovascular manifestations
       Q8742Marfan syndrome with ocular manifestations
       Q8743Marfan syndrome with skeletal manifestations
       Q874Marfan syndrome
      Ehlers-Danlos syndrome
       Q7960Ehlers-Danlos syndrome, unspecified
       Q7961Classical Ehlers-Danlos syndrome
       Q7962Hypermobile Ehlers-Danlos syndrome
       Q7963Vascular Ehlers-Danlos syndrome
       Q7969Other Ehlers-Danlos syndrome
       Q796Ehlers-Danlos syndrome
      Turner syndrome
       Q960Turner syndrome karyotype 45, X
       Q961Turner syndrome karyotype 46, X iso (Xq)
       Q962Turner syndrome karyotype 46, X with abnormal sex chromosome, except iso (Xq)
       Q963Turner syndrome mosaicism, 45, X/46, XX or XY
       Q964Turner syndrome mosaicism, 45, X/other cell line(s) with abnormal sex chromosome
       Q968Turner syndrome, other variants of Turner syndrome
       Q969Turner syndrome, unspecified
       Q96Turner syndrome
      Diabetes
       E101Type 1 diabetes mellitus with ketoacidosis
       E1010Type 1 diabetes mellitus with ketoacidosis without coma
       E1011Type 1 diabetes mellitus with ketoacidosis with coma
       E102Type 1 diabetes mellitus with kidney complications
       E1021Type 1 diabetes mellitus with diabetic nephropathy
       E1022Type 1 diabetes mellitus with diabetic chronic kidney disease
       E1029Type 1 diabetes mellitus with other diabetic kidney complication
       E103Type 1 diabetes mellitus with ophthalmic complications
       E1031Type 1 diabetes mellitus with unspecified diabetic retinopathy
       E10311Type 1 diabetes mellitus with unspecified diabetic retinopathy with macular edema
       E10319Type 1 diabetes mellitus with unspecified diabetic retinopathy without macular edema
       E1032Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy
       E10321Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema
       E103211Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema right eye
       E103212Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema left eye
       E103213Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema bilateral
       E103219Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema unspecified eye
       E10329Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema
       E103291Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema right eye
       E103292Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema left eye
       E103293Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema bilateral
       E103299Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema unspecified eye
       E1033Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy
       E10331Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema
       E103311Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema right eye
       E103312Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema left eye
       E103313Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema bilateral
       E103319Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema unspecified eye
       E10339Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema
       E103391Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema right eye
       E103392Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema left eye
       E103393Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema bilateral
       E103399Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema unspecified eye
       E1034Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy
       E10341Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema
       E103411Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema right eye
       E103412Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema left eye
       E103413Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema bilateral
       E103419Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema unspecified eye
       E10349Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema
       E103491Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema right eye
       E103492Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema left eye
       E103493Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema bilateral
       E103499Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema unspecified eye
       E1035Type 1 diabetes mellitus with proliferative diabetic retinopathy
       E10351Type 1 diabetes mellitus with proliferative diabetic retinopathy with macular edema
       E103511Type 1 diabetes mellitus with proliferative diabetic retinopathy with macular edema right eye
       E103512Type 1 diabetes mellitus with proliferative diabetic retinopathy with macular edema left eye
       E103513Type 1 diabetes mellitus with proliferative diabetic retinopathy with macular edema bilateral
       E103519Type 1 diabetes mellitus with proliferative diabetic retinopathy with macular edema unspecified eye
       E10352Type 1 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment involving the macula
       E103521Type 1 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment involving the macula right eye
       E103522Type 1 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment involving the macula left eye
       E103523Type 1 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment involving the macula bilateral
       E103529Type 1 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment involving the macula unspecified eye
       E10353Type 1 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment not involving the macula
       E103531Type 1 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment not involving the macula
       E103532Type 1 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment not involving the macula left eye
       E103533Type 1 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment not involving macula bilateral
       E103539Type 1 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment not involving macula unspecified eye
       E10354Type 1 diabetes mellitus with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment
       E103541Type 1 diabetes mellitus with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment right eye
       E103542Type 1 diabetes mellitus with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment left eye
       E103543Type 1 diabetes mellitus with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment bilateral
       E103549Type 1 diabetes mellitus with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment unspecified eye
       E10355Type 1 diabetes mellitus with stable proliferative diabetic retinopathy
       E103551Type 1 diabetes mellitus with stable proliferative diabetic retinopathy right eye
       E103552Type 1 diabetes mellitus with stable proliferative diabetic retinopathy left eye
       E103553Type 1 diabetes mellitus with stable proliferative diabetic retinopathy bilateral
       E103559Type 1 diabetes mellitus with stable proliferative diabetic retinopathy unspecified eye
       E10359Type 1 diabetes mellitus with proliferative diabetic retinopathy without macular edema
       E103591Type 1 diabetes mellitus with proliferative diabetic retinopathy without macular edema right eye
       E103592Type 1 diabetes mellitus with proliferative diabetic retinopathy without macular edema left eye
       E103593Type 1 diabetes mellitus with proliferative diabetic retinopathy without macular edema bilateral
       E103599Type 1 diabetes mellitus with proliferative diabetic retinopathy without macular edema unspecified eye
       E1036Type 1 diabetes mellitus with diabetic cataract
       E1037Type 1 diabetes mellitus with diabetic macular edema, resolved following treatment
       E1037X1Type 1 diabetes mellitus with diabetic macular edema, resolved following treatment right eye
       E1037X2Type 1 diabetes mellitus with diabetic macular edema, resolved following treatment left eye
       E1037X3Type 1 diabetes mellitus with diabetic macular edema, resolved following treatment bilateral
       E1037X9Type 1 diabetes mellitus with diabetic macular edema, resolved following treatment unspecified eye
       E1039Type 1 diabetes mellitus with other diabetic ophthalmic complication
       E104Type 1 diabetes mellitus with neurological complications
       E1040Type 1 diabetes mellitus with diabetic neuropathy, unspecified
       E1041Type 1 diabetes mellitus with diabetic mononeuropathy
       E1042Type 1 diabetes mellitus with diabetic polyneuropathy
       E1043Type 1 diabetes mellitus with diabetic autonomic (poly)neuropathy
       E1044Type 1 diabetes mellitus with diabetic amyotrophy
       E1049Type 1 diabetes mellitus with other diabetic neurologic complication
       E105Type 1 diabetes mellitus with circulatory complications
       E1051Type 1 diabetes mellitus with diabetic peripheral angiopathy without gangrene
       E1052Type 1 diabetes mellitus with diabetic peripheral angiopathy with gangrene
       E1059Type 1 diabetes mellitus with other circulatory complications
       E106Type 1 diabetes mellitus with other specified complications
       E1061Type 1 diabetes mellitus with diabetic arthropathy
       E10610Type 1 diabetes mellitus with diabetic neuropathic arthropathy
       E10618Type 1 diabetes mellitus with other diabetic arthropathy
       E1062Type 1 diabetes mellitus with skin complications
       E10620Type 1 diabetes mellitus with diabetic dermatitis
       E10621Type 1 diabetes mellitus with foot ulcer
       E10622Type 1 diabetes mellitus with other skin ulcer
       E10628Type 1 diabetes mellitus with other skin complications
       E1063Type 1 diabetes mellitus with oral complications
       E10630Type 1 diabetes mellitus with periodontal disease
       E10638Type 1 diabetes mellitus with other oral complications
       E1064Type 1 diabetes mellitus with hypoglycemia
       E10641Type 1 diabetes mellitus with hypoglycemia with coma
       E10649Type 1 diabetes mellitus with hypoglycemia without coma
       E1065Type 1 diabetes mellitus with hyperglycemia
       E1069Type 1 diabetes mellitus with other specified complication
       E108Type 1 diabetes mellitus with unspecified complications
       E109Type 1 diabetes mellitus without complications
       E110Type 2 diabetes mellitus with hyperosmolarity
       E1100Type 2 diabetes mellitus with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC)
       E1101Type 2 diabetes mellitus with hyperosmolarity with coma
       E111Type 2 diabetes mellitus with ketoacidosis
       E1110Type 2 diabetes mellitus with ketoacidosis without coma
       E1111Type 2 diabetes mellitus with ketoacidosis with coma
       E112Type 2 diabetes mellitus with kidney complications
       E1121Type 2 diabetes mellitus with diabetic nephropathy
       E1122Type 2 diabetes mellitus with diabetic chronic kidney disease
       E1129Type 2 diabetes mellitus with other diabetic kidney complication
       E113Type 2 diabetes mellitus with ophthalmic complications
       E1131Type 2 diabetes mellitus with unspecified diabetic retinopathy
       E11311Type 2 diabetes mellitus with unspecified diabetic retinopathy with macular edema
       E11319Type 2 diabetes mellitus with unspecified diabetic retinopathy without macular edema
       E1132Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy
       E11321Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema
       E113211Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema right eye
       E113212Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema left eye
       E113213Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema bilateral
       E113219Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema unspecified eye
       E11329Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema
       E113291Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema right eye
       E113292Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema left eye
       E113293Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema bilateral
       E113299Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema unspecified eye
       E1133Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy
       E11331Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema
       E113311Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema right eye
       E113312Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema left eye
       E113313Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema bilateral
       E113319Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema unspecified eye
       E11339Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema
       E113391Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema right eye
       E113392Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema left eye
       E113393Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema bilateral
       E113399Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema unspecified eye
       E1134Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy
       E11341Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema
       E113411Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema right eye
       E113412Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema left eye
       E113413Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema bilateral
       E113419Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema unspecified eye
       E11349Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema
       E113491Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema right eye
       E113492Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema left eye
       E113493Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema bilateral
       E113499Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema unspecified eye
       E1135Type 2 diabetes mellitus with proliferative diabetic retinopathy
       E11351Type 2 diabetes mellitus with proliferative diabetic retinopathy with macular edema
       E113511Type 2 diabetes mellitus with proliferative diabetic retinopathy with macular edema right eye
       E113512Type 2 diabetes mellitus with proliferative diabetic retinopathy with macular edema left eye
       E113513Type 2 diabetes mellitus with proliferative diabetic retinopathy with macular edema bilateral
       E113519Type 2 diabetes mellitus with proliferative diabetic retinopathy with macular edema unspecified eye
       E11352Type 2 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment involving the macula
       E113521Type 2 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment involving the macula right eye
       E113522Type 2 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment involving the macula left eye
       E113523Type 2 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment involving the macula bilateral
       E113529Type 2 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment involving the macula unspecified eye
       E11353Type 2 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment not involving macula
       E113531Type 2 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment not involving macula right eye
       E113532Type 2 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment not involving macula left eye
       E113533Type 2 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment not involving macula bilateral
       E113539Type 2 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment not involving macula unspecified eye
       E11354Type 2 diabetes mellitus with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment
       E113541Type 2 diabetes mellitus with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment right eye
       E113542Type 2 diabetes mellitus with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment left eye
       E113543Type 2 diabetes mellitus with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment bilateral
       E113549Type 2 diabetes mellitus with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment unspecified eye
       E11355Type 2 diabetes mellitus with stable proliferative diabetic retinopathy
       E113551Type 2 diabetes mellitus with stable proliferative diabetic retinopathy right eye
       E113552Type 2 diabetes mellitus with stable proliferative diabetic retinopathy left eye
       E113553Type 2 diabetes mellitus with stable proliferative diabetic retinopathy bilateral
       E113559Type 2 diabetes mellitus with stable proliferative diabetic retinopathy unspecified eye
       E11359Type 2 diabetes mellitus with proliferative diabetic retinopathy without macular edema
       E113591Type 2 diabetes mellitus with proliferative diabetic retinopathy without macular edema right eye
       E113592Type 2 diabetes mellitus with proliferative diabetic retinopathy without macular edema left eye
       E113593Type 2 diabetes mellitus with proliferative diabetic retinopathy without macular edema bilateral
       E113599Type 2 diabetes mellitus with proliferative diabetic retinopathy without macular edema unspecified eye
       E1136Type 2 diabetes mellitus with diabetic cataract
       E1137Type 2 diabetes mellitus with diabetic macular edema, resolved following treatment
       E1137X1Type 2 diabetes mellitus with diabetic macular edema, resolved following treatment right eye
       E1137X2Type 2 diabetes mellitus with diabetic macular edema, resolved following treatment left eye
       E1137X3Type 2 diabetes mellitus with diabetic macular edema, resolved following treatment bilateral
       E1137X9Type 2 diabetes mellitus with diabetic macular edema, resolved following treatment unspecified eye
       E1139Type 2 diabetes mellitus with other diabetic ophthalmic complication
       E114Type 2 diabetes mellitus with neurological complications
       E1140Type 2 diabetes mellitus with diabetic neuropathy, unspecified
       E1141Type 2 diabetes mellitus with diabetic mononeuropathy
       E1142Type 2 diabetes mellitus with diabetic polyneuropathy
       E1143Type 2 diabetes mellitus with diabetic autonomic (poly)neuropathy
       E1144Type 2 diabetes mellitus with diabetic amyotrophy
       E1149Type 2 diabetes mellitus with other diabetic neurological complication
       E115Type 2 diabetes mellitus with circulatory complications
       E1151Type 2 diabetes mellitus with diabetic peripheral angiopathy without gangrene
       E1152Type 2 diabetes mellitus with diabetic peripheral angiopathy with gangrene
       E1159Type 2 diabetes mellitus with other circulatory complications
       E116Type 2 diabetes mellitus with other specified complications
       E1161Type 2 diabetes mellitus with diabetic arthropathy
       E11610Type 2 diabetes mellitus with diabetic neuropathic arthropathy
       E11618Type 2 diabetes mellitus with other diabetic arthropathy
       E1162Type 2 diabetes mellitus with skin complications
       E11620Type 2 diabetes mellitus with diabetic dermatitis
       E11621Type 2 diabetes mellitus with foot ulcer
       E11622Type 2 diabetes mellitus with other skin ulcer
       E11628Type 2 diabetes mellitus with other skin complications
       E1163Type 2 diabetes mellitus with oral complications
       E11630Type 2 diabetes mellitus with periodontal disease
       E11638Type 2 diabetes mellitus with other oral complications
       E1164Type 2 diabetes mellitus with hypoglycemia
       E11641Type 2 diabetes mellitus with hypoglycemia with coma
       E11649Type 2 diabetes mellitus with hypoglycemia without coma
       E1165Type 2 diabetes mellitus with hyperglycemia
       E10Type I diabetes
       E11Type II diabetes
      Prior cardiac surgery
       Z951Presence of aortocoronary bypass graft
       Z952Presence of prosthetic heart valve
       Z953Presence of xenogenic heart valve
       Z954Presence of other heart valve replacement
       Z955Presence of coronary angioplasty implant and graft
       Z958Presence of other cardiac and vascular implants and grafts
       Z95810Presence of automatic (implantable) cardiac defibrillator
       Z95811Presence of heart assist device
       Z95812Presence of fully implantable artificial heart
       Z95818Presence of other cardiac implants and grafts
       Z9582Presence of other vascular implants and grafts
       Z95820Peripheral vascular angioplasty status with implants and grafts
       Z95828Presence of other vascular implants and grafts
       Z959Presence of cardiac and vascular implant and graft, unspecified
       Z95Presence of vascular implants and grafts on presentation
      Chronic heart disease
       I25Chronic ischemic heart disease
       I251Atherosclerotic heart disease of native coronary artery
       I2510Atherosclerotic heart disease of native coronary artery without angina pectoris
       I2511Atherosclerotic heart disease of native coronary artery with angina pectoris
       I25110Atherosclerotic heart disease of native coronary artery with unstable angina pectoris
       I25111Atherosclerotic heart disease of native coronary artery with unstable angina pectoris with documented spasm
       I25118Atherosclerotic heart disease of native coronary artery with other forms of angina pectoris
       I25119Atherosclerotic heart disease of native coronary artery with unspecified angina pectoris
       I252Old myocardial infarction
       I253Aneurysm of heart
       I254Coronary artery aneurysm and dissection
       I2541Coronary artery aneurysm
       I2542Coronary artery dissection
       I255Ischemic cardiomyopathy
       I256Silent myocardial ischemia
       I257Atherosclerosis of coronary artery bypass graft(s) and coronary artery of transplanted heart with angina pectoris
       I2570Atherosclerosis of coronary artery bypass graft(s), unspecified, with angina pectoris
       I25700Atherosclerosis of coronary artery bypass graft(s), unspecified, with unstable angina pectoris
       I25701Atherosclerosis of coronary artery bypass graft(s), unspecified, with unstable angina pectoris with documented spasm
       I25708Atherosclerosis of coronary artery bypass graft(s), unspecified, with other forms of angina pectoris
       I25709Atherosclerosis of coronary artery bypass graft(s), unspecified, with unspecified angina pectoris
       I2571Atherosclerosis of autologous vein coronary artery bypass graft(s) with angina pectoris
       I25710Atherosclerosis of autologous vein coronary artery bypass graft(s) with unstable angina pectoris
       I25711Atherosclerosis of autologous vein coronary artery bypass graft(s) with unstable angina pectoris with documented spasm
       I25718Atherosclerosis of autologous vein coronary artery bypass graft(s) with other forms of angina pectoris
       I25719Atherosclerosis of autologous vein coronary artery bypass graft(s) with unspecified angina pectoris
       I2572Atherosclerosis of autologous artery coronary artery bypass graft(s) with angina pectoris
       I25720Atherosclerosis of autologous artery coronary artery bypass graft(s) with unstable angina pectoris
       I25721Atherosclerosis of autologous artery coronary artery bypass graft(s) with unstable angina pectoris with documented spasm
       I25728Atherosclerosis of autologous artery coronary artery bypass graft(s) with other forms of angina pectoris
       I25729Atherosclerosis of autologous artery coronary artery bypass graft(s) with unspecified angina pectoris
       I2573Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with angina pectoris
       I25730Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unstable angina pectoris
       I25731Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unstable angina pectoris with documented spasm
       I25738Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with other forms of angina pectoris
       I25739Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unspecified angina pectoris
       I2575Atherosclerosis of native coronary artery of transplanted heart with angina pectoris
       I25750Atherosclerosis of native coronary artery of transplanted heart with unstable angina
       I25751Atherosclerosis of native coronary artery of transplanted heart with unstable angina with documented spasm
       I25758Atherosclerosis of native coronary artery of transplanted heart with other forms of angina pectoris
       I25759Atherosclerosis of native coronary artery of transplanted heart with unspecified angina pectoris
       I2576Atherosclerosis of bypass graft of coronary artery of transplanted heart with angina pectoris
       I25760Atherosclerosis of bypass graft of coronary artery of transplanted heart with unstable angina
       I25761Atherosclerosis of bypass graft of coronary artery of transplanted heart with unstable angina with documented spasm
       I25768Atherosclerosis of bypass graft of coronary artery of transplanted heart with other forms of angina pectoris
       I25769Atherosclerosis of bypass graft of coronary artery of transplanted heart with unspecified angina pectoris
       I2579Atherosclerosis of other coronary artery bypass graft(s) with angina pectoris
       I25790Atherosclerosis of other coronary artery bypass graft(s) with unstable angina pectoris
       I25791Atherosclerosis of other coronary artery bypass graft(s) with unstable angina pectoris with documented spasm
       I25798Atherosclerosis of other coronary artery bypass graft(s) with other forms of angina pectoris
       I25799Atherosclerosis of other coronary artery bypass graft(s) with unspecified angina pectoris
       I258Other forms of chronic ischemic heart disease
       I2581Atherosclerosis of other coronary vessels without angina pectoris
       I25810Atherosclerosis of coronary artery bypass graft(s) without angina pectoris
       I25811Atherosclerosis of native coronary artery of transplanted heart without angina pectoris
       I25812Atherosclerosis of bypass graft of coronary artery of transplanted heart without angina pectoris
       I2582Chronic total occlusion of coronary artery
       I2583Coronary atherosclerosis due to lipid rich plaque
       I2584Coronary atherosclerosis due to calcified coronary lesion
       I2589Other forms of chronic ischemic heart disease
       I259Chronic ischemic heart disease, unspecified
      Chronic kidney disease
       N18Chronic kidney disease (CKD)
       N18.1Chronic kidney disease, stage 1
       N18.2Chronic kidney disease, stage 2 (mild)
       N18.3Chronic kidney disease, stage 3 (moderate)
       N18.30Chronic kidney disease, stage 3 unspecified
       N18.31Chronic kidney disease, stage 3a
       N18.32Chronic kidney disease, stage 3b
       N18.4Chronic kidney disease, stage 4 (severe)
       N18.5Chronic kidney disease, stage 5
       N18.6End-stage renal disease
       N18.9Chronic kidney disease, unspecified
      Aortic aneurysm
       I71.1Thoracic aortic aneurysm, ruptured
       I71.2Thoracic aortic aneurysm, without rupture
       I71.3Abdominal aortic aneurysm, ruptured
       I71.4Abdominal aortic aneurysm, without rupture
       I71.5Thoracoabdominal aortic aneurysm, ruptured
       I71.6Thoracoabdominal aortic aneurysm, without rupture
       I71.8Aortic aneurysm of unspecified site, ruptured
       I71.9Aortic aneurysm of unspecified site, without rupture
      Obesity
       Z6843Body mass index 50-59.9
       E669Obesity
      Cardiac inflammation
       M314Takayasu (aortic arch syndrome)
       M315Giant cell arteritis with polymyalgia rheumatica
       M316Other giant cell arteritis
       A5200Cardiovascular syphilis, unspecified
       A5201Syphilitic aneurysm of aorta
       A5202Syphilitic aortitis
       A5203Syphilitic endocarditis
       A5206Other syphilitic heart involvement
       A5209Other cardiovascular syphilis
       A1884Tuberculosis of heart
       Z950Presence of cardiac pacemaker
       Q231Congenital insufficiency of aortic valve
       Z8673Personal history of transient ischemic attack (TIA), and cerebral infarction without residual deficits
      Preoperative shock
       R57.0Cardiogenic shock
       R57.1Hypovolemic shock
       R57.8Other shock
       R57.9Shock, unspecified
      ICD-10, International Classification of Diseases, Tenth Revision.
      Table E3ICD-10 codes for complications
      ICD-10 codeDescription
      Postprocedural shock/cardiac failure
       T8110XAPostprocedural shock unspecified, initial encounter
       T8111XAPostprocedural cardiogenic shock, initial encounter
       T8112XAPostprocedural septic shock, initial encounter
       T8119XAOther postprocedural shock
       T882Shock due to anesthesia
       T882XXAShock due to anesthesia initial encounter
       I970Postcardiotomy syndrome
       I97110Postprocedural cardiac insufficiency following cardiac surgery
       I97120Postprocedural cardiac arrest following cardiac surgery
       I97130Postprocedural heart failure following cardiac surgery
       I97190Other postprocedural cardiac functional disturbances following cardiac surgery
       I97710Intraoperative cardiac arrest during cardiac surgery
       I97790Other intraoperative cardiac functional disturbances during cardiac surgery
       I977Intraoperative cardiac functional disturbances
       I97711Intraoperative cardiac arrest during other surgery
       I97791Other intraoperative cardiac functional disturbances during other surgery
       I971Other postprocedural cardiac functional disturbances
       I97121Postprocedural cardiac arrest following other surgery
       I97131Postprocedural heart failure following other surgery
       I97191Other postprocedural cardiac functional disturbances following other surgery
       I9788Other intraoperative complications of the circulatory system, not elsewhere classified
       I9789Other procedural complications and disorders of the circulatory system, not elsewhere classified
      Pulmonary complications
       Z9911Dependence on a ventilator
       Z930Tracheostomy status
       0B110D6Bypass trachea to esophagus with intraluminal device, open approach
       0B110F4Bypass trachea to cutaneous with tracheostomy device, open approach
       0B110Z4Bypass trachea to cutaneous, open approach
       0B113F4Bypass trachea to cutaneous with tracheostomy device, percutaneous approach
       0B113Z4Bypass trachea to cutaneous, percutaneous approach
       0B114F4Bypass trachea to cutaneous with tracheostomy device, percutaneous endoscopic approach
       0B114Z4Bypass trachea to cutaneous, percutaneous endoscopic approach
       J952Acute pulmonary insufficiency following nonthoracic surgery
       J95821Acute postprocedural respiratory failure
       J951Acute pulmonary insufficiency following thoracic surgery
       J95822Acute and chronic postprocedural respiratory failure
       J95851Ventilator-associated pneumonia
       J95859Other complication of respirator
       J9588Chronic pulmonary insufficiency following surgery
       T8282XAEmphysema (subcutaneous) resulting from a procedure, initial encounter
       J950Tracheostomy complications
       J9500Unspecified tracheostomy complication
       J9501Hemorrhage from tracheostomy stoma
       J9502Infection of tracheostomy stoma
       J9503Malfunction of tracheostomy stoma
       J9504Tracheoesophageal fistula following tracheostomy
       J9509Other tracheostomy complication
       J951Acute pulmonary insufficiency following thoracic surgery
       J952Acute pulmonary insufficiency following nonthoracic surgery
       J953Chronic pulmonary insufficiency following surgery
       J954Chemical pneumonitis due to anesthesia
       J955Postprocedural subglottic stenosis
       J956Intraoperative hemorrhage and hematoma of a respiratory system organ or structure complicating a procedure
       J9561Intraoperative hemorrhage and hematoma of a respiratory system organ or structure complicating a respiratory system procedure
       J9562Intraoperative hemorrhage and hematoma of a respiratory system organ or structure complicating other procedure
       J957Accidental puncture and laceration of a respiratory system organ or structure during a procedure
       J9571Accidental puncture and laceration of a respiratory system organ or structure during a respiratory system procedure
       J9572Accidental puncture and laceration of a respiratory system organ or structure during other procedure
       J958Other intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified
       J9581Postprocedural pneumothorax and air leak
       J95811Postprocedural pneumothorax
       J95812Postprocedural air leak
       J9582Postprocedural respiratory failure
       J95821Acute postprocedural respiratory failure
       J95822Acute and chronic postprocedural respiratory failure
       J9583Postprocedural hemorrhage of a respiratory system organ or structure following a procedure
       J95830Postprocedural hemorrhage of a respiratory system organ or structure following a respiratory system procedure
       J95831Postprocedural hemorrhage of a respiratory system organ or structure following other procedure
       J9584Transfusion-related acute lung injury (TRALI)
       J9585Complication of respirator [ventilator]
       J95850Mechanical complication of respirator
       J95851Ventilator-associated pneumonia
       J95859Other complication of respirator [ventilator]
       J9586Postprocedural hematoma and seroma of a respiratory system organ or structure following a procedure
       J95860Postprocedural hematoma of a respiratory system organ or structure following a respiratory system procedure
       J95861Postprocedural hematoma of a respiratory system organ or structure following other procedure
       J95862Postprocedural seroma of a respiratory system organ or structure following a respiratory system procedure
       J95863Postprocedural seroma of a respiratory system organ or structure following other procedure
       J9588Other intraoperative complications of respiratory system, not elsewhere classified
       J9589Other postprocedural complications and disorders of respiratory system, not elsewhere classified
       Z990Dependence on aspirator
       Z991Dependence on respirator
       Z9912Encounter for respirator [ventilator] dependence during power failure
       Z9981Dependence on supplemental oxygen
       0B110D6Bypass trachea to esophagus with intraluminal device, open approach
       0B110F4Bypass trachea to cutaneous with tracheostomy device, open approach
       0B110Z4Bypass trachea to cutaneous, open approach
       0B113F4Bypass trachea to cutaneous with tracheostomy device, percutaneous approach
       0B113Z4Bypass trachea to cutaneous, percutaneous approach
       0B114F4Bypass trachea to cutaneous with tracheostomy device, percutaneous endoscopic approach
       0B114Z4Bypass trachea to cutaneous, percutaneous endoscopic approach
      Hemorrhage/hematoma/seroma
       I97410Intraoperative hemorrhage and hematoma of a circulatory system organ or structure complicating a cardiac catheterization
       I97411Intraoperative hemorrhage and hematoma of a circulatory system organ or structure complicating a cardiac bypass
       I97418Intraoperative hemorrhage and hematoma of a circulatory system organ or structure complicating other circulatory system procedure
       I9742Intraoperative hemorrhage and hematoma of a circulatory system organ or structure complicating other procedure
       I97610Postprocedural hemorrhage of a circulatory system organ or structure following cardiac catheterization
       I97611Postprocedural hemorrhage of a circulatory system organ or structure following cardiac bypass
       I97618Postprocedural hemorrhage of a circulatory system organ or structure following other circulatory system procedure
       I97620Postprocedural hemorrhage of a circulatory system organ or structure following other procedure
       I97621Postprocedural hematoma of a circulatory system organ or structure following other procedure
       I97630Postprocedural hematoma of a circulatory system organ or structure following cardiac catheterization
       I97631Postprocedural hematoma of a circulatory system organ or structure following cardiac bypass
       I97638Postprocedural hematoma of a circulatory system organ or structure following other circulatory system procedure
       I97622Postprocedural seroma of a circulatory system organ or structure following other procedure
       I97640Postprocedural seroma of a circulatory system organ or structure following a cardiac catheterization
       I97641Postprocedural seroma of a circulatory system organ or structure following cardiac bypass
       I97648Postprocedural seroma of a circulatory system organ or structure following other circulatory system procedure
       I9761Postprocedural hemorrhage of a circulatory system organ or structure following a circulatory system procedure
       I9762Postprocedural hemorrhage, hematoma, and seroma of a circulatory system organ or structure following other procedure
       I9763Postprocedural hematoma of a circulatory system organ or structure following a circulatory system procedure
       I9764Postprocedural seroma of a circulatory system organ or structure following a circulatory system procedure
      Stroke
       I97810Intraoperative cerebrovascular infarction during cardiac surgery
       I97820Postprocedural cerebrovascular infarction following cardiac surgery
      Adverse reaction
       T886Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered
       T886XXAAnaphylactic reaction due to adverse effect of correct drug or medicament properly administered, initial encounter
       T887Unspecified adverse effect of drug or medicament
       T887XXAUnspecified adverse effect of drug or medicament, initial encounter
       Y83Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
       Y830Surgical operation with transplant of whole organ as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
       Y831Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
       Y832Surgical operation with anastomosis, bypass or graft as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
       Y833Surgical operation with formation of external stoma as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
       Y834Other reconstructive surgery as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
       Y835Amputation of limb(s) as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
       Y836Removal of other organ (partial) (total) as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
       Y838Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
       Y839Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
       T886Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered
       T886XXAAnaphylactic reaction due to adverse effect of correct drug or medicament properly administered, initial encounter
       T887Unspecified adverse effect of drug or medicament
       T887XXAUnspecified adverse effect of drug or medicament, initial encounter
       Y832Surgical operation with anastomosis, bypass, or graft as the cause of abnormal reaction
       Y839Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
      Catheter-related complication
       T801XXAVascular complications following infusion, transfusion and therapeutic injection, initial encounter
       T80219AUnspecified infection due to central venous catheter, initial encounter
       T80211ABloodstream infection due to central venous catheter, initial encounter
       T80212ALocal infection due to central venous catheter, initial encounter
       T8022XAAcute infection following transfusion, infusion, or injection of blood or blood products, initial encounter
       T8029XAInfection following other infusion, transfusion, and therapeutic injection, initial encounter
       T800Air embolism following infusion, transfusion, and therapeutic injection
       T801Vascular complications following infusion, transfusion and therapeutic injection
       T801XXAVascular complications following infusion, transfusion and therapeutic injection, initial encounter
       T802Infections following infusion, transfusion and therapeutic injection
       T8021Infection due to central venous catheter
       T80211Bloodstream infection due to central venous catheter
       T80211ABloodstream infection due to central venous catheter, initial encounter
       T80212Local infection due to central venous catheter
       T80212ALocal infection due to central venous catheter, initial encounter
       T80218Other infection due to central venous catheter
       T80 218AOther infection due to central venous catheter, initial encounter
       T80219Unspecified infection due to central venous catheter
       T80219AUnspecified infection due to central venous catheter, initial encounter
       T8022Acute infection following transfusion, infusion, or injection of blood and blood products
       T8022XAAcute infection following transfusion, infusion, or injection of blood and blood products, initial encounter
       T8029Acute infection following other transfusion, infusion, or injection of blood and blood products, initial encounter
       T8029XAAcute infection following transfusion, infusion, or injection of blood and blood products, initial encounter, initial encounter
      Postprocedural hypertension
       I973Postprocedural hypertension
      Other unspecified complications
       T888Other specified complications of surgical and medical care, not elsewhere classified
       T889Complication of surgical and medical care, unspecified
       T889XXAComplication of surgical and medical care, unspecified initial encounter
       Z99Dependence on enabling machines and devices, not elsewhere classified
       Z998Dependence on other enabling machines and devices
       Z9989Dependence on other enabling machines and devices
       T888XXAOther specified complications of surgical and medical care, not elsewhere classified, initial encounter
       T8132XADisruption of internal operation (surgical) wound, not elsewhere classified, initial encounter
       K6811Postprocedural retroperitoneal abscess
      ICD-10, International Classification of Diseases, Tenth Revision.
      Figure thumbnail fx4
      Figure E1Cubic spline of the Elixhauser comorbidity index.

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