Glossary of Abbreviations:AV (Atrioventricular), AVSD (Atrioventricular septal defect), CAVVO (Common AV valve orifice), LAVV (Left AV valve), LVOT (Left ventricular outflow tract), LVOTO (Left ventricular outflow tract obstruction), VSD (Ventricular Septal Defect)
Publication stageIn Press Journal Pre-Proof
Disclosure Statement: No conflict of interest declared
Funding Statement: None
Institutional Review Board (IRB) Approval: The institutional review group approved the release and use of confidential patient data (project reference number 18-013 LVOT in AVSD, approval February 2019).
Informed Consent Statement: The need for research consent was waived by the Medical Research Council and NHS (National Health Service) UK Health Research Authority criteria.
Central Image: Surgical repair further altered LVOT morphometrics in AVSD with complete AV valve orifice.
Our findings suggest that surgical repair has further effect on the LVOT in AVSD with common AV valve orifice, adding to the burden on a native outflow tract that is already intrinsically narrow.
Pre-repair, majority of AVSD patients had proportionate LV outflow tract morphometry. Post-repair, there were greater disproportionate morphometry and lower subaortic z-scores, with a greater burden seen following modified 1-patch repair. The LV outflow tract in control VSD group was unaffected by surgical repair. The clinical implications from this morphometric study remains to be further evaluated.
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